![]() We propose the combined use of MSC and cord blood CD34+cells may be useful in the treatment of autism. Cord blood CD34+ cells are known to be potent angiogenic stimulators, having demonstrated positive effects in not only peripheral ischemia, but also in models of cerebral ischemia.Īdditionally, anecdotal clinical cases have reported responses in autistic children receiving cord blood CD34+ cells. For example, mesenchymal stem cell (MSC) transplantation helps manage autism spectrum disorder. Recent advances in stem cell therapy have given hope to those suffering from autism. Exosomes secreted by stem cells might mediate stem-cell-related therapeutic actions. Mesenchymal stem cells (MSC) are in late phases of clinical development for treatment of graft versus host disease and Crohn’s Disease, two conditions of immune dysregulation. Stem cells secreting exosomes that can be used in exosome therapy for autism. These appear to be causative since correlation of altered inflammatory responses, and hypoperfusion with symptology is reported. Autistic disorder, or autism is the most common form of ASD.Īlthough several neurophysiological alterations have been associated with autism, immune abnormalities and neural hypoperfusion appear to be broadly consistent. “After we’ve concluded the Phase II trial, we will have much more information and should be able to better characterize the potential for this therapy.Autism spectrum disorders (ASD) are a group of neurodevelopmental conditions whose incidence is reaching epidemic proportions, afflicting approximately 1 in 166 children. ![]() “It’s very common for parents to be seeking alternative treatments for autism, and that’s why it’s important to stress that right now, we do not have clear evidence that cord blood is an effective therapy for autism,” Dawson said. Dawson is also president of the International Society for Autism Research. “One of the most challenging things for parents of children with autism is that there is so much information out there that is unreliable,” said Geraldine Dawson, PhD, co-principal investigator and director of the Duke Center for Autism and Brain Development. (Note to parents: This does not apply to children who have already registered for screening and are still being evaluated for enrollment in the trial.) The trial is expected to be complete in 2019. Initial screening for the trial is complete, and the research team is no longer seeking additional subjects. The researchers are now leading a larger, controlled Phase II clinical trial at Duke to determine whether the initial suggestion of benefit to children with autism spectrum disorder can be replicated. There is much work still to be done in much larger, randomized clinical studies before we can draw any firm conclusions about effectiveness.” This treatment significantly prevented progression to further phases of the disease. “But parents of children with autism should not interpret these results as conclusively showing effectiveness of this treatment. Stem cell therapy has shown very positive results in patients with autism. “We are cautiously optimistic about these early findings,” said Duke Pediatric Bone Marrow Transplant Specialist Joanne Kurtzberg, MD, who is a principal investigator of the study. The researchers caution that the small trial was not designed to evaluate whether a cord blood infusion is effective in improving autism symptoms, and results were not measured against data from a placebo group. The Phase I trial was designed to evaluate the safety of treating children with autism with an IV infusion of their own umbilical cord blood, which their families opted to bank at birth. The study found that among 25 children ages 2 to 5, more than two-thirds appeared to show improvements in speech, socialization, and eye contact, as reported by parents and assessed by researchers. Results from a Phase I trial were published April 5 in the journal Stem Cells Translational Medicine.
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